TNNT2

Across TCGA patient cohorts, TNNT2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNT2-associated genes across cancer lineages are Cyclin-B1, Bcl-2, and MEK1. Each is linked with TNNT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNNT2-to-partner and partner-to-TNNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TNNT2-low versus TNNT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNT2→partner) and Y-score (partner→TNNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.506	+2.321	.016	.033	3	3
SKCM	Bcl-2 →	-0.385	-2.459	.025	.020	3	2
UCEC	MEK1 →	+0.471	+2.906	<.001	.001	3	2
UCEC	MSH2 →	-0.346	-3.880	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.328	+1.884	.007	.030	3	2
UCEC	14-3-3_beta →	-0.110	-3.673	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Cyclin-B1 by TNNT2 expression — UCEC

Explore this box plot interactively →