TNNT2

Across TCGA pan-cancer cohorts, TNNT2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TNNT2 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TNNT2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TNNT2 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LGG show a favorable association.

KIRP, DLBC, and COAD are the cancer types where TNNT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.712	0.926	.001	76	view →
DLBC	DFS	Median	II,III,IV	1.000	0.551	<.001	60	view →
COAD	OS	Median	All	0.518	0.728	.001	48	view →
READ	DFS	Median	IV	0.364	0.822	.001	26	view →
THCA	OS	Median	IV	0.566	0.939	.004	24	view →
LUAD	DFS	Tertile	II,III,IV	0.601	0.750	.006	22	view →
ACC	OS	Tertile	All	0.669	1.000	<.001	21	view →
SCLC	DFS	Quartile	All	0.427	0.926	.001	18	view →
PRAD	DFS	Median	All	0.811	0.954	<.001	16	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	15	view →
LGG	DFS	Quartile	All	0.889	0.710	<.001	14	view →
BLCA	OS	Tertile	IV	0.238	0.691	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TNNT2–KIRP (OS)

Open the KIRP breakdown →