TNNT2

Across TCGA cell cohorts, TNNT2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TNNT2-associated genes across cancer lineages are SLC17A1, OTOP3, and MPEG1. Each is linked with TNNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNT2-to-partner and partner-to-TNNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A1 grouped by TNNT2-low versus TNNT2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNT2→partner) and Y-score (partner→TNNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC17A1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	OTOP3 →	+0.015	+3.930	<.001	.003	3	1
SKIN	MPEG1 →	+0.033	+3.920	<.001	.005	3	1
LARGE_INTESTINE	RASGEF1C →	+0.236	+3.404	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SLC17A1 by TNNT2 expression — SKIN

Explore this box plot interactively →