TNNT1

Across TCGA cell cohorts, TNNT1 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNNT1-associated genes across cancer lineages are Niraparib, 123829, and Dihydrorotenone. Each is linked with TNNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNT1-to-partner and partner-to-TNNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by TNNT1-low versus TNNT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNT1→partner) and Y-score (partner→TNNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.412	+2.646	.020	.047	3	1
LARGE_INTESTINE	123829 →	+0.576	+2.649	.048	.046	3	1
LARGE_INTESTINE	Dihydrorotenone →	+0.406	+2.649	.049	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.527	+2.646	.035	.047	3	1
LARGE_INTESTINE	CZC24832 →	+0.301	+2.646	.020	.047	1	1
LARGE_INTESTINE	Wnt-C59 →	+0.373	+2.646	.033	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Niraparib by TNNT1 expression — LARGE_INTESTINE

Explore this box plot interactively →