TNNT1

Across TCGA pan-cancer cohorts, TNNT1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TNNT1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TNNT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNNT1 is over-expressed in tumor, although a few such as PRAD and KICH show the opposite, repressed pattern.

LUAD, COAD, and BLCA are the cancer types where TNNT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNNT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+4.091	<.001	11	view →
COAD	All	II,III,IV	+1.476	<.001	10	view →
BLCA	Male	All	+3.398	<.001	7	view →
KIRC	Male	All	+0.700	<.001	7	view →
LUSC	Male	II,III,IV	+3.525	<.001	6	view →
BRCA	All	III,IV	+2.885	<.001	6	view →
KIRP	All	All	+1.171	.002	5	view →
LIHC	All	All	+0.512	.004	5	view →
READ	Male	All	+1.743	.005	4	view →
PAAD	All	All	+3.795	.039	2	view →
CHOL	All	All	+3.651	<.001	2	view →
STAD	All	II,III,IV	+1.036	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TNNT1–LUAD

Open the LUAD breakdown →