TNNI3

Across TCGA patient cohorts, TNNI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,014 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI3-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Nucleolar large rRNA transcription by RNA polymerase I, and Positive regulation of telomerase RNA localization to Cajal body. Each is linked with TNNI3 in more than 20 cancer types. Because this analysis shows association rather than direction, both TNNI3-to-partner and partner-to-TNNI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by TNNI3-low versus TNNI3-high in KICH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI3→partner) and Y-score (partner→TNNI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	rRNA pseudouridine synthesis →	+0.049	+0.720	.002	<.001	1	21
STAD	Nucleolar large rRNA transcription by RNA polymerase I →	+0.032	+0.424	.001	.006	1	17
LAML	Positive regulation of telomerase RNA localization to Cajal body →	+0.049	+0.484	<.001	.001	3	15
LIHC	rRNA transcription →	+0.032	+0.488	<.001	<.001	3	15
KICH	tRNA thio-modification →	+0.058	+0.736	<.001	<.001	2	16
STAD	Regulation of DNA-directed DNA polymerase activity →	+0.043	+0.489	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,014 associations by consensus.

rRNA pseudouridine synthesis by TNNI3 expression — KICH

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