TNNI3

Across TCGA pan-cancer cohorts, TNNI3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TNNI3 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TNNI3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNNI3 expression acts as an unfavorable survival marker, although some lineages such as UVM and SCLC show a favorable association.

KIRC, UVM, and COAD are the cancer types where TNNI3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.548	0.699	<.001	95	view →
UVM	DFS	Median	II,III,IV	0.743	0.426	<.001	94	view →
COAD	DFS	Median	II,III,IV	0.583	0.738	<.001	62	view →
ACC	DFS	Median	All	0.281	0.625	<.001	33	view →
PAAD	OS	Median	II,III,IV	0.496	0.684	.001	26	view →
SCLC	DFS	Quartile	II,III,IV	0.776	0.337	.011	25	view →
LIHC	OS	Median	All	0.415	0.626	.005	19	view →
PCPG	DFS	Quartile	All	0.531	0.950	.004	18	view →
KIRP	DFS	Quartile	All	0.944	0.838	.018	13	view →
DLBC	OS	Tertile	II,III,IV	0.294	1.000	.012	13	view →
LGG	OS	Quartile	All	0.576	0.329	.003	12	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TNNI3–KIRC (DFS)

Open the KIRC breakdown →