TNNI3

Across TCGA patient cohorts, TNNI3 mutation is significantly associated with the RNA expression of many other genes, with 1,063 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI3-associated genes across cancer lineages are ABHD3, FBXO22, and TIGAR. Each is linked with TNNI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNI3-to-partner and partner-to-TNNI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD3 grouped by TNNI3-low versus TNNI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI3→partner) and Y-score (partner→TNNI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABHD3 →	+0.854	+3.711	<.001	<.001	3	2
UCEC	FBXO22 →	+0.625	+3.732	<.001	<.001	3	2
UCEC	TIGAR →	+0.738	+3.362	<.001	.005	3	2
UCEC	ITGAE →	+0.569	+3.700	<.001	.001	3	2
BRCA	RNU6-1115P →	+0.554	+5.841	<.001	.003	3	2
LUSC	RN7SKP202 →	+0.424	+5.102	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,063 associations by consensus.

ABHD3 by TNNI3 expression — UCEC

Explore this box plot interactively →