TNNC2

Across TCGA patient cohorts, TNNC2 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNC2-associated genes across cancer lineages are IGKV2-38, RN7SL237P, and ATP6V1E1P2. Each is linked with TNNC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNC2-to-partner and partner-to-TNNC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV2-38 grouped by TNNC2-low versus TNNC2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNC2→partner) and Y-score (partner→TNNC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGKV2-38 →	+0.189	+7.640	<.001	.009	3	2
UCEC	RN7SL237P →	+0.421	+2.496	<.001	.009	3	1
UCEC	ATP6V1E1P2 →	+0.299	+3.077	<.001	.001	3	1
UCEC	NF1P7 →	+0.109	+2.940	<.001	.005	3	1
UCEC	DNAJA3 →	+0.792	+3.250	<.001	.008	3	1
UCEC	FGF21 →	+0.590	+3.983	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

IGKV2-38 by TNNC2 expression — BLCA

Explore this box plot interactively →