TNNC1

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TNNC1 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible TNNC1-associated genes across cancer lineages are CD4+ Tcm and CLP. Each is linked with TNNC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNC1-to-partner and partner-to-TNNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by TNNC1-low versus TNNC1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNC1→partner) and Y-score (partner→TNNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUSCCD4+ Tcm →+0.009+5.593.004.03031
SKCMCLP →+0.107+3.019.016.01911
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tcm by TNNC1 expression — LUSC

Box plot of CD4+ Tcm in TNNC1-low vs TNNC1-high samples in LUSC.

Explore this box plot interactively →

Exploration