TNNC1

Across TCGA pan-cancer cohorts, TNNC1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TNNC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNNC1 RNA is repressed in tumor relative to normal tissue. In most cancer types TNNC1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where TNNC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNNC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−3.406	<.001	12	view →
KICH	Female	II,III,IV	−3.451	<.001	10	view →
LUSC	Female	II,III,IV	−6.197	<.001	9	view →
LUAD	Female	II,III,IV	−4.723	<.001	9	view →
KIRP	Male	II,III,IV	−2.986	<.001	9	view →
HNSC	Male	All	−3.095	.002	8	view →
UCEC	All	All	+2.222	<.001	8	view →
LIHC	All	II,III,IV	+1.619	<.001	8	view →
COAD	All	All	+1.096	<.001	7	view →
THCA	All	II,III,IV	−0.989	<.001	5	view →
STAD	All	All	+0.740	.002	4	view →
PAAD	Female	All	+0.629	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TNNC1–KIRC

Open the KIRC breakdown →