TNN

Across TCGA pan-cancer cohorts, TNN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNN data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TNN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNN expression acts as an unfavorable survival marker.

LUAD, CCRCC, and LSCC are the cancer types where TNN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.341	0.848	.002	22	view →
CCRCC	OS	Median	III,IV	0.668	0.945	.008	10	view →
LSCC	DFS	Quartile	II,III,IV	0.701	1.000	.025	5	view →
HNSC	DFS	Median	All	0.577	0.766	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNN–LUAD (OS)

Open the LUAD breakdown →