TNN

Across TCGA pan-cancer cohorts, TNN mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TNN’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TNN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TNN is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

PDAC, CCRCC, and LUAD are the cancer types where TNN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+0.783	<.001	6	view →
CCRCC	All	III,IV	−0.327	.003	6	view →
LUAD	All	All	+0.328	.009	4	view →
LSCC	All	All	+0.227	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TNN–PDAC

Open the PDAC breakdown →