TNN

Across TCGA patient cohorts, TNN mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TNN-associated genes across cancer lineages are FoxM1, 4E-BP1, and ASNS. Each is linked with TNN in more than 5 cancer types. Because this analysis shows association rather than direction, both TNN-to-partner and partner-to-TNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TNN-low versus TNN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNN→partner) and Y-score (partner→TNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.196	+4.033	.007	<.001	3	6
STAD	4E-BP1 →	+0.445	+3.087	<.001	<.001	3	5
COAD	ASNS →	+0.412	+1.686	.002	.013	3	4
STAD	eIF4E →	+0.186	+3.190	.004	.008	3	3
STAD	ER-alpha →	-0.152	-2.393	.014	.003	3	3
STAD	PCNA →	+0.252	+3.459	.016	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

FoxM1 by TNN expression — LUAD

Explore this box plot interactively →