TNN

Across TCGA cell cohorts, TNN RNA expression is significantly associated with the go_rna of many other GO terms, with 815 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNN-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Regulation of endopeptidase activity, and Protein N-linked glycosylation. Each is linked with TNN in more than 4 cancer types. Because this analysis shows association rather than direction, both TNN-to-partner and partner-to-TNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by TNN-low versus TNN-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNN→partner) and Y-score (partner→TNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of response to endoplasmic reticulum stress →	+0.087	+0.026	<.001	.005	3	5
BLOOD_Leukemia	Regulation of endopeptidase activity →	+0.157	+0.485	<.001	.005	3	4
BLOOD_Leukemia	Protein N-linked glycosylation →	+0.030	+0.859	.008	<.001	3	4
LARGE_INTESTINE	Positive regulation of stem cell proliferation →	+0.144	+0.013	<.001	.009	3	3
STOMACH	Positive regulation of potassium ion import across plasma membrane →	-0.230	-0.068	<.001	.009	2	4
BLOOD_Myeloma	GTP biosynthetic process →	+0.103	+1.033	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 815 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by TNN expression — LARGE_INTESTINE

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