TNN

Across TCGA cell cohorts, TNN protein abundance is significantly associated with the RNA expression of many other genes, with 1,731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNN-associated genes across cancer lineages are POP5, ORC1, and ANKHD1. Each is linked with TNN in more than 3 cancer types. Because this analysis shows association rather than direction, both TNN-to-partner and partner-to-TNN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNN versus POP5 in LIVER, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNN→partner) and Y-score (partner→TNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	POP5 →	-0.862	-1.587	.009	.001	3	4
LIVER	ORC1 →	-0.886	-1.133	.003	.001	3	4
LUNG_NSCLC_LUSC	ANKHD1 →	-1.274	-0.870	.002	.003	3	4
CNS	NDRG2 →	-1.797	-0.838	<.001	<.001	3	4
LIVER	MEGF6 →	+4.705	+1.517	<.001	.002	3	3
LIVER	VMAC →	+1.097	+1.247	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,731 associations by consensus.

TNN vs POP5 — LIVER

Explore this scatter interactively →