TNN

Across TCGA cell cohorts, TNN mutation is significantly associated with the RNA expression of many other genes, with 1,359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNN-associated genes across cancer lineages are TCEANC2, S100PBP, and FBXL5. Each is linked with TNN in more than 2 cancer types. Because this analysis shows association rather than direction, both TNN-to-partner and partner-to-TNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCEANC2 grouped by TNN-low versus TNN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNN→partner) and Y-score (partner→TNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TCEANC2 →	+0.341	+3.252	.002	.002	3	3
LARGE_INTESTINE	S100PBP →	+0.692	+2.265	<.001	.001	3	3
LARGE_INTESTINE	FBXL5 →	+0.411	+2.949	.006	<.001	3	3
LARGE_INTESTINE	DCK →	+0.713	+2.949	<.001	<.001	3	3
LARGE_INTESTINE	CCDC171 →	+0.336	+3.087	.001	.006	3	3
LARGE_INTESTINE	FBXW10 →	+0.168	+2.562	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,359 associations by consensus.

TCEANC2 by TNN expression — LARGE_INTESTINE

Explore this box plot interactively →