TNKS2

Across TCGA pan-cancer cohorts, TNKS2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNKS2 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TNKS2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TNKS2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and GBM are the cancer types where TNKS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	1.000	0.820	.006	48	view →
LSCC	DFS	Median	II,III,IV	0.915	0.485	<.001	45	view →
GBM	OS	Quartile	All	0.306	0.703	.022	6	view →
HNSC	OS	Tertile	All	0.912	0.646	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNKS2–UCEC (OS)

Open the UCEC breakdown →