TNKS2

Across TCGA pan-cancer cohorts, TNKS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TNKS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TNKS2 RNA is repressed in tumor relative to normal tissue. In most cancer types TNKS2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and CHOL are the cancer types where TNKS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNKS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.449	<.001	7	view →
KICH	Female	All	−1.090	<.001	6	view →
CHOL	All	All	+1.296	.001	3	view →
LIHC	Female	II,III,IV	+0.535	.030	3	view →
HNSC	Female	III,IV	+0.877	.021	2	view →
BLCA	Male	III,IV	+0.629	.020	2	view →
UCEC	All	All	−0.453	.031	2	view →
KIRC	All	All	+0.234	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TNKS2–THCA

Open the THCA breakdown →