TNKS2

Across TCGA patient cohorts, TNKS2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,866 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TNKS2-associated genes across cancer lineages are LDHB, ODC1, and PDCL3. Each is linked with TNKS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNKS2-to-partner and partner-to-TNKS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNKS2 versus LDHB in OV, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS2→partner) and Y-score (partner→TNKS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LDHB →	+2.254	+1.007	.003	.006	3	3
HNSC	ODC1 →	+2.313	+0.878	.001	<.001	3	3
LUAD	PDCL3 →	+0.556	+0.655	<.001	<.001	3	2
LSCC	PDSS1 →	+0.545	+0.444	<.001	.009	3	2
BRCA	ZNF175 →	-0.763	-0.841	.003	.003	3	2
BRCA	LFNG →	-1.665	-0.834	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,866 associations by consensus.

TNKS2 vs LDHB — OV

Explore this scatter interactively →