TNKS2

Across TCGA patient cohorts, TNKS2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNKS2-associated genes across cancer lineages are ATM, eEF2, and JNK2. Each is linked with TNKS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNKS2-to-partner and partner-to-TNKS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TNKS2-low versus TNKS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS2→partner) and Y-score (partner→TNKS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.450	-3.794	.001	<.001	3	3
UCEC	eEF2 →	+0.277	+2.000	.015	.029	3	2
UCEC	JNK2 →	+0.204	+1.512	.001	.017	3	2
UCEC	mTOR_pS2448 →	-0.140	-2.074	.003	.004	3	2
UCEC	Rab25 →	-0.330	-2.415	.001	.002	3	2
UCEC	TIGAR →	+0.111	+1.316	.022	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by TNKS2 expression — UCEC

Explore this box plot interactively →