TNKS2

Across TCGA cell cohorts, TNKS2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNKS2-associated genes across cancer lineages are KNCN, USP17L3, and OR12D3. Each is linked with TNKS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNKS2-to-partner and partner-to-TNKS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNCN grouped by TNKS2-low versus TNKS2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS2→partner) and Y-score (partner→TNKS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KNCN →	+0.007	+4.491	<.001	.002	3	1
KIDNEY	USP17L3 →	+0.014	+4.491	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR12D3 →	+0.025	+5.228	.001	.005	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.321	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PHF12 →	+0.646	+3.137	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

KNCN by TNKS2 expression — KIDNEY

Explore this box plot interactively →