TNKS2

Across TCGA cell cohorts, TNKS2 mutation is significantly associated with the mutation status of many other genes, with 5,328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNKS2-associated genes across cancer lineages are SPTB, ADGRA3, and LTBP1. Each is linked with TNKS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TNKS2-to-partner and partner-to-TNKS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTB grouped by TNKS2-low versus TNKS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS2→partner) and Y-score (partner→TNKS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPTB →	+2.029	+3.287	<.001	<.001	1	5
OVARY	ADGRA3 →	+4.415	+4.977	.007	.007	1	4
BLOOD_Lymphoma	LTBP1 →	+3.847	+5.108	.001	.001	1	4
BLOOD_Leukemia	ERBB3 →	+3.177	+3.531	<.001	<.001	1	4
BLOOD_Leukemia	NEO1 →	+3.247	+3.050	.008	.008	1	4
LARGE_INTESTINE	ATP2B1 →	+2.070	+2.807	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,328 associations by consensus.

SPTB by TNKS2 expression — LARGE_INTESTINE

Explore this box plot interactively →