TNK1

Across TCGA pan-cancer cohorts, TNK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNK1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TNK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TNK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where TNK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.852	0.231	.025	8	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.933	.025	3	view →
PDAC	DFS	Median	All	0.260	0.427	.036	2	view →
LSCC	OS	Quartile	All	0.903	0.735	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNK1–UCEC (DFS)

Open the UCEC breakdown →