TNK1

Across TCGA patient cohorts, TNK1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNK1-associated genes across cancer lineages are MYH11, Notch1, and Rictor. Each is linked with TNK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNK1-to-partner and partner-to-TNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by TNK1-low versus TNK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNK1→partner) and Y-score (partner→TNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYH11 →	+1.512	+2.700	.003	.006	3	1
UCEC	Notch1 →	+0.178	+3.469	.004	.002	3	1
UCEC	Rictor →	+0.755	+2.331	.003	.019	3	1
UCEC	VEGFR2 →	+0.284	+2.999	.034	.035	3	1
UCEC	Caveolin-1 →	+0.681	+2.000	.037	.032	3	1
UCEC	Chk2 →	-0.278	-3.459	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MYH11 by TNK1 expression — UCEC

Explore this box plot interactively →