TNK1

Across TCGA cell cohorts, TNK1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNK1-associated genes across cancer lineages are LILRA5, IDI2, and DEFA4. Each is linked with TNK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNK1-to-partner and partner-to-TNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA5 grouped by TNK1-low versus TNK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNK1→partner) and Y-score (partner→TNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LILRA5 →	+0.026	+3.562	<.001	.002	3	2
LARGE_INTESTINE	IDI2 →	+0.023	+2.994	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4N5 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	ETDC →	+0.488	+5.228	<.001	.005	3	1
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

LILRA5 by TNK1 expression — LARGE_INTESTINE

Explore this box plot interactively →