TNIP3

Across TCGA patient cohorts, TNIP3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNIP3-associated genes across cancer lineages are Cyclin-B1, ATM, and 4E-BP1. Each is linked with TNIP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNIP3-to-partner and partner-to-TNIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TNIP3-low versus TNIP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIP3→partner) and Y-score (partner→TNIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.494	+2.584	.008	.011	3	2
UCEC	ATM →	-0.466	-1.584	.001	.005	3	2
UCEC	4E-BP1 →	+0.293	+3.807	<.001	<.001	3	2
LUSC	MIG-6 →	+0.138	+2.816	.034	.036	3	1
SKCM	ACC_pS79 →	+0.268	+2.584	.045	.011	3	1
SKCM	ACC1 →	+0.342	+2.584	.017	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Cyclin-B1 by TNIP3 expression — SKCM

Explore this box plot interactively →