TNIP3

Across TCGA pan-cancer cohorts, TNIP3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TNIP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNIP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNIP3 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, KIRP, and STAD are the cancer types where TNIP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNIP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.123	<.001	10	view →
KIRP	All	All	+0.446	.001	8	view →
STAD	All	All	+0.714	.001	7	view →
HNSC	All	All	+0.662	.002	6	view →
LUSC	Male	II,III,IV	−1.678	<.001	4	view →
BRCA	All	All	+0.312	<.001	4	view →
ESCA	All	II,III,IV	+0.459	.007	3	view →
KICH	Female	All	−0.104	.036	2	view →
LUAD	Male	II,III,IV	−0.826	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TNIP3–KIRC

Open the KIRC breakdown →