TNIP2P1

Across TCGA patient cohorts, TNIP2P1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNIP2P1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with TNIP2P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNIP2P1-to-partner and partner-to-TNIP2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TNIP2P1-low versus TNIP2P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIP2P1→partner) and Y-score (partner→TNIP2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.128	-2.295	.003	.033	3	1
UCEC	EGFR_pY1068 →	-0.261	-2.584	.017	.010	3	1
UCEC	A-Raf_pS299 →	-0.130	-2.321	.013	.034	3	1
UCEC	GAPDH →	+0.526	+2.999	.024	.035	3	1
UCEC	Ku80 →	+0.223	+2.820	.030	.001	3	1
UCEC	MSH2 →	-0.432	-2.558	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by TNIP2P1 expression — UCEC

Explore this box plot interactively →