Across TCGA pan-cancer cohorts, TNIP2P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TNIP2P1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNIP2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNIP2P1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
HNSC, COAD, and LUAD are the cancer types where TNIP2P1 tumor–normal differential expression is most reproducible.