TNIP1

Across TCGA pan-cancer cohorts, TNIP1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TNIP1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TNIP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNIP1 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

HNSC, OV, and COAD are the cancer types where TNIP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.082	0.712	<.001	30	view →
OV	DFS	Median	All	0.142	0.541	.002	12	view →
COAD	DFS	Median	All	0.192	0.696	.005	12	view →
LUSC	OS	Median	All	0.081	0.818	<.001	12	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.315	0.707	.009	9	view →
CHOL	DFS	Median	All	0.037	0.486	.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	OS	Median	III,IV	0.197	0.684	.013	3	view →
STAD	OS	Median	IV	0.771	0.300	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TNIP1–HNSC (DFS)

Open the HNSC breakdown →