TNFSF8

Across TCGA patient cohorts, TNFSF8 mutation is significantly associated with the RNA expression of many other genes, with 583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF8-associated genes across cancer lineages are CRLF3P1, ZNRF1, and RNU6-1119P. Each is linked with TNFSF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF8-to-partner and partner-to-TNFSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRLF3P1 grouped by TNFSF8-low versus TNFSF8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF8→partner) and Y-score (partner→TNFSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CRLF3P1 →	+0.014	+3.009	<.001	.009	3	2
UCEC	ZNRF1 →	+0.590	+2.721	<.001	.003	3	2
STAD	RNU6-1119P →	+0.297	+5.366	.008	.005	3	2
UCEC	RNY1P1 →	+0.212	+3.335	<.001	.004	3	2
BLCA	MIR615 →	+0.438	+5.411	<.001	.005	3	2
UCEC	LINC02217 →	+0.074	+2.071	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 583 associations by consensus.

CRLF3P1 by TNFSF8 expression — SKCM

Explore this box plot interactively →