TNFSF8

Across TCGA pan-cancer cohorts, TNFSF8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TNFSF8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFSF8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFSF8 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where TNFSF8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFSF8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.603	<.001	12	view →
COAD	Female	All	−0.621	<.001	9	view →
LUSC	Male	II,III,IV	−1.380	<.001	7	view →
KIRP	All	All	+0.632	<.001	5	view →
KICH	All	II,III,IV	−0.716	.001	4	view →
BRCA	Female	All	+0.357	<.001	4	view →
STAD	Female	All	+0.992	.037	2	view →
BLCA	All	All	−0.550	.027	2	view →
CHOL	All	II,III,IV	−0.520	.017	2	view →
THCA	All	All	−0.431	.018	2	view →
READ	Female	All	−0.999	.031	1	view →
ESCA	All	All	+0.835	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TNFSF8–KIRC

Open the KIRC breakdown →