TNFSF8

Across TCGA patient cohorts, TNFSF8 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF8-associated genes across cancer lineages are Rab11, Annexin-1, and TFRC. Each is linked with TNFSF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF8-to-partner and partner-to-TNFSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab11 grouped by TNFSF8-low versus TNFSF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF8→partner) and Y-score (partner→TNFSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.160	-3.169	.044	.020	3	1
UCEC	Annexin-1 →	+0.876	+3.169	.002	.020	3	1
UCEC	TFRC →	+0.726	+3.169	.012	.020	2	1
UCEC	ARID1A →	-0.239	-3.162	.016	.019	1	1
UCEC	4E-BP1_pT70 →	+0.130	+3.169	.039	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Rab11 by TNFSF8 expression — UCEC

Explore this box plot interactively →