TNFSF11

Across TCGA cell cohorts, TNFSF11 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFSF11-associated genes across cancer lineages are LORICRIN, USP17L18, and C20orf85. Each is linked with TNFSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF11-to-partner and partner-to-TNFSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LORICRIN grouped by TNFSF11-low versus TNFSF11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF11→partner) and Y-score (partner→TNFSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LORICRIN →	+0.029	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP17L18 →	+0.006	+4.887	<.001	.009	3	1
BLOOD_Leukemia	C20orf85 →	+0.032	+5.969	<.001	.001	3	1
BLOOD_Leukemia	CST8 →	+0.031	+5.969	.001	.001	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

LORICRIN by TNFSF11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →