TNFSF10

Across TCGA pan-cancer cohorts, TNFSF10 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TNFSF10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNFSF10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TNFSF10 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where TNFSF10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFSF10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.700	<.001	8	view →
LUAD	Male	All	−0.569	<.001	8	view →
PDAC	Female	II,III,IV	+1.146	<.001	4	view →
CCRCC	All	All	+0.213	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TNFSF10–HNSC

Open the HNSC breakdown →