TNFSF10

Across TCGA pan-cancer cohorts, TNFSF10 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TNFSF10 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TNFSF10 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TNFSF10 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and PAAD are the cancer types where TNFSF10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.426	0.239	<.001	132	view →
KIRC	DFS	Tertile	II,III,IV	0.703	0.337	<.001	60	view →
PAAD	OS	Tertile	All	0.343	0.641	<.001	52	view →
UVM	DFS	Tertile	II,III,IV	0.285	0.603	.012	40	view →
THYM	DFS	Quartile	All	0.741	0.973	.005	38	view →
UCEC	DFS	Quartile	All	0.497	0.764	.018	18	view →
PRAD	DFS	Tertile	All	0.899	0.668	<.001	18	view →
SARC	OS	Median	All	0.878	0.652	<.001	17	view →
CESC	DFS	Quartile	All	0.908	0.756	.007	16	view →
ESCA	DFS	Quartile	III,IV	0.682	0.406	.008	16	view →
LGG	OS	Tertile	All	0.395	0.554	.004	14	view →
KIRP	DFS	Median	All	0.978	0.803	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TNFSF10–SKCM (OS)

Open the SKCM breakdown →