TNFSF10

Across TCGA cell cohorts, TNFSF10 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,540 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TNFSF10-associated GO terms across cancer lineages are Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, Negative regulation of response to biotic stimulus, and Apoptotic signaling pathway. Each is linked with TNFSF10 in more than 14 cancer types. Because this analysis shows association rather than direction, both TNFSF10-to-partner and partner-to-TNFSF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of exogenous peptide antigen via MHC class Ib grouped by TNFSF10-low versus TNFSF10-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF10→partner) and Y-score (partner→TNFSF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.217	+0.515	.004	.001	3	15
PANCREAS	Negative regulation of response to biotic stimulus →	+0.076	+2.093	<.001	<.001	3	15
BONE	Apoptotic signaling pathway →	+0.060	+0.643	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cytokine-mediated signaling pathway →	+0.126	+2.975	.005	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of peptide antigen via MHC class I →	+0.176	+2.814	.005	.001	3	14
LUNG_NSCLC_LUAD	Intrinsic apoptotic signaling pathway →	+0.060	+1.953	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,540 associations by consensus.

Antigen processing and presentation of exogenous peptide antigen via MHC class Ib by TNFSF10 expression — BONE

Explore this box plot interactively →