TNFSF10

Across TCGA cell cohorts, TNFSF10 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TNFSF10-associated genes across cancer lineages are GALNTL5, CCL7, and KCNA10. Each is linked with TNFSF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF10-to-partner and partner-to-TNFSF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by TNFSF10-low versus TNFSF10-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF10→partner) and Y-score (partner→TNFSF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALNTL5 →	+0.029	+5.415	<.001	.004	3	2
BLOOD_Lymphoma	CCL7 →	+0.122	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KCNA10 →	+0.016	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TMCO5A →	+0.156	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	DYDC1 →	+1.404	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR5P3 →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GALNTL5 by TNFSF10 expression — SKIN

Explore this box plot interactively →