TNFRSF8

Across TCGA patient cohorts, TNFRSF8 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,942 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TNFRSF8-associated proteins across cancer lineages are ARHGAP45, SKAP2, and STK10. Each is linked with TNFRSF8 in more than 9 cancer types. Because this analysis shows association rather than direction, both TNFRSF8-to-partner and partner-to-TNFRSF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNFRSF8 versus ARHGAP45 in GBM, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF8→partner) and Y-score (partner→TNFRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.619	+0.602	<.001	<.001	3	10
GBM	SKAP2 →	+0.742	+0.606	<.001	<.001	3	10
LSCC	STK10 →	+0.412	+0.454	<.001	<.001	3	10
HNSC	CORO1A →	+0.656	+0.903	<.001	<.001	3	10
GBM	DOCK2 →	+0.690	+0.592	<.001	<.001	3	10
GBM	FERMT3 →	+0.589	+0.547	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,942 associations by consensus.

TNFRSF8 vs ARHGAP45 — GBM

Explore this scatter interactively →