TNFRSF8

Across TCGA patient cohorts, TNFRSF8 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF8-associated genes across cancer lineages are PCNA, 4E-BP1, and eIF4E. Each is linked with TNFRSF8 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNFRSF8-to-partner and partner-to-TNFRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TNFRSF8-low versus TNFRSF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF8→partner) and Y-score (partner→TNFRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.265	+3.700	<.001	.001	3	4
UCEC	4E-BP1 →	+0.434	+3.029	<.001	<.001	3	3
UCEC	eIF4E →	+0.258	+3.459	<.001	<.001	3	2
UCEC	FoxM1 →	+0.331	+2.916	<.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.112	-2.077	.012	.005	3	2
UCEC	Ku80 →	+0.244	+1.594	.004	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PCNA by TNFRSF8 expression — UCEC

Explore this box plot interactively →