TNFRSF8

Across TCGA cell cohorts, TNFRSF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,489 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TNFRSF8-associated GO terms across cancer lineages are Cytoplasmic translation, Protein folding, and Positive regulation of apoptotic signaling pathway. Each is linked with TNFRSF8 in more than 8 cancer types. Because this analysis shows association rather than direction, both TNFRSF8-to-partner and partner-to-TNFRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by TNFRSF8-low versus TNFRSF8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF8→partner) and Y-score (partner→TNFRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cytoplasmic translation →	+0.086	+0.200	<.001	.003	3	9
PANCREAS	Protein folding →	+0.065	+0.202	<.001	.005	2	9
BLOOD_Lymphoma	Positive regulation of apoptotic signaling pathway →	+0.042	+2.447	.006	.003	3	8
BLOOD_Lymphoma	Response to type I interferon →	+0.111	+4.234	<.001	<.001	3	7
BLOOD_Lymphoma	Cellular response to type I interferon →	+0.121	+3.964	<.001	<.001	3	7
BLOOD_Lymphoma	Energy derivation by oxidation of organic compounds →	+0.035	+2.285	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,489 associations by consensus.

Cytoplasmic translation by TNFRSF8 expression — BONE

Explore this box plot interactively →