TNFRSF8

Across TCGA cell cohorts, TNFRSF8 mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFRSF8-associated genes across cancer lineages are Lestaurtinib, RVX-208, and GW-2580. Each is linked with TNFRSF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF8-to-partner and partner-to-TNFRSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lestaurtinib grouped by TNFRSF8-low versus TNFRSF8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF8→partner) and Y-score (partner→TNFRSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Lestaurtinib →	+0.502	+2.710	.044	.043	3	1
LARGE_INTESTINE	RVX-208 →	+0.345	+2.868	.017	.022	3	1
LARGE_INTESTINE	GW-2580 →	+0.289	+2.786	.025	.037	3	1
LARGE_INTESTINE	Vinorelbine →	+0.654	+2.807	.039	.046	3	1
LARGE_INTESTINE	GSK690693 →	+0.589	+2.791	.019	.028	3	1
LARGE_INTESTINE	Bortezomib →	+0.320	+2.649	.032	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Lestaurtinib by TNFRSF8 expression — LARGE_INTESTINE

Explore this box plot interactively →