TNFRSF6B

Across TCGA cell cohorts, TNFRSF6B mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFRSF6B-associated genes across cancer lineages are OR4A47, ESX1, and KRT35. Each is linked with TNFRSF6B in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF6B-to-partner and partner-to-TNFRSF6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A47 grouped by TNFRSF6B-low versus TNFRSF6B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF6B→partner) and Y-score (partner→TNFRSF6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR4A47 →	+0.012	+3.802	<.001	.001	3	2
BLOOD_Myeloma	ESX1 →	+0.126	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRT35 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	PIGY →	+0.846	+4.807	.001	.006	3	1
LARGE_INTESTINE	PROKR1 →	+0.047	+4.047	<.001	.001	3	1
LARGE_INTESTINE	RESP18 →	+0.022	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR4A47 by TNFRSF6B expression — BLOOD_Leukemia

Explore this box plot interactively →