TNFRSF21

Across TCGA patient cohorts, TNFRSF21 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF21-associated genes across cancer lineages are TFRC, ATM, and Caspase-7-cleavedD198. Each is linked with TNFRSF21 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF21-to-partner and partner-to-TNFRSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TNFRSF21-low versus TNFRSF21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF21→partner) and Y-score (partner→TNFRSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.776	+3.169	.003	.018	3	3
UCEC	ATM →	-0.427	-1.415	.012	.046	3	3
UCEC	Caspase-7-cleavedD198 →	+0.466	+1.720	.036	.025	3	3
SKCM	p62 Lck ligand →	-0.378	-2.987	.041	.035	3	2
UCEC	eIF4E →	+0.157	+3.013	.047	.018	3	2
UCEC	mTOR_pS2448 →	-0.141	-2.571	.011	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by TNFRSF21 expression — SKCM

Explore this box plot interactively →