TNFRSF21

Across TCGA pan-cancer cohorts, TNFRSF21 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TNFRSF21’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TNFRSF21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF21 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where TNFRSF21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+2.300	<.001	9	view →
THCA	Male	All	+1.716	<.001	9	view →
LUSC	All	III,IV	+2.575	<.001	8	view →
LIHC	Female	II,III,IV	+1.884	<.001	7	view →
STAD	Male	II,III,IV	+1.427	<.001	6	view →
UCEC	All	All	+1.147	<.001	6	view →
BRCA	All	II,III,IV	−0.955	<.001	6	view →
CHOL	Male	All	+4.506	<.001	5	view →
HNSC	Male	All	+1.025	<.001	5	view →
KICH	All	All	−0.797	.005	5	view →
BLCA	All	IV	+2.255	.012	4	view →
PAAD	All	All	+2.092	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TNFRSF21–LUAD

Open the LUAD breakdown →