TNFRSF21

Across TCGA cell cohorts, TNFRSF21 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,725 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TNFRSF21-associated GO terms across cancer lineages are Negative regulation of interleukin-5 production, B cell apoptotic process, and Negative regulation of interleukin-13 production. Each is linked with TNFRSF21 in more than 16 cancer types. Because this analysis shows association rather than direction, both TNFRSF21-to-partner and partner-to-TNFRSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of interleukin-5 production grouped by TNFRSF21-low versus TNFRSF21-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF21→partner) and Y-score (partner→TNFRSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of interleukin-5 production →	+1.672	+1.986	<.001	<.001	3	17
OESOPHAGUS	B cell apoptotic process →	+0.301	+2.268	<.001	<.001	3	15
KIDNEY	Negative regulation of interleukin-13 production →	+1.258	+1.998	<.001	<.001	3	15
STOMACH	Wound healing →	+0.096	+2.474	.005	.002	3	13
BONE	Negative regulation of cell adhesion →	+0.110	+2.760	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Cellular response to tumor necrosis factor →	+0.113	+2.244	.005	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,725 associations by consensus.

Negative regulation of interleukin-5 production by TNFRSF21 expression — SOFT_TISSUE

Explore this box plot interactively →