TNFRSF21

Across TCGA cell cohorts, TNFRSF21 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFRSF21-associated genes across cancer lineages are PPDPFL, HSFY1, and ARGFX. Each is linked with TNFRSF21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF21-to-partner and partner-to-TNFRSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPDPFL grouped by TNFRSF21-low versus TNFRSF21-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF21→partner) and Y-score (partner→TNFRSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPDPFL →	+0.069	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	HSFY1 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ARGFX →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BHLHA9 →	+0.150	+4.095	.007	.009	3	1
LARGE_INTESTINE	CENPVL1 →	+0.286	+4.095	<.001	.009	3	1
LARGE_INTESTINE	AMELY →	+0.045	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PPDPFL by TNFRSF21 expression — LARGE_INTESTINE

Explore this box plot interactively →