TNFRSF1A

Across TCGA patient cohorts, TNFRSF1A mutation is significantly associated with the RNA expression of many other genes, with 1,808 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF1A-associated genes across cancer lineages are RN7SKP221, RNU6-1321P, and MIR191. Each is linked with TNFRSF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF1A-to-partner and partner-to-TNFRSF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by TNFRSF1A-low versus TNFRSF1A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF1A→partner) and Y-score (partner→TNFRSF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
SKCM	RNU6-1321P →	+0.253	+3.211	.007	.005	3	2
STAD	MIR191 →	+0.283	+3.008	.009	.009	3	2
UCEC	RNA5SP109 →	+0.122	+3.059	<.001	.005	3	2
UCEC	EEF1GP4 →	+0.119	+2.010	<.001	.006	3	2
UCEC	TET2-AS1 →	+0.248	+2.474	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,808 associations by consensus.

RN7SKP221 by TNFRSF1A expression — BRCA

Explore this box plot interactively →