TNFRSF1A

Across TCGA pan-cancer cohorts, TNFRSF1A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TNFRSF1A data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TNFRSF1A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF1A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UVM, LGG, and LUAD are the cancer types where TNFRSF1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.410	0.814	<.001	121	view →
LGG	DFS	Median	All	0.639	0.834	<.001	51	view →
LUAD	DFS	Tertile	All	0.243	0.461	<.001	47	view →
UCEC	DFS	Tertile	II,III,IV	0.734	0.273	.005	40	view →
HNSC	OS	Quartile	All	0.311	0.512	.001	34	view →
SKCM	OS	Quartile	II,III,IV	0.434	0.242	.002	19	view →
ESCA	DFS	Median	All	0.904	0.322	.007	18	view →
KIRC	DFS	Quartile	II,III,IV	0.590	0.785	.017	16	view →
OV	OS	Quartile	III,IV	0.248	0.343	.010	16	view →
THCA	DFS	Median	All	0.909	0.653	.005	15	view →
LIHC	OS	Tertile	All	0.518	0.791	.006	11	view →
SCLC	DFS	Median	All	0.955	0.578	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TNFRSF1A–UVM (OS)

Open the UVM breakdown →